Glutathione...What It Is, What It Does
and How To Get It

The secret is out on Glutathione. First discovered in 1888, it took almost one-hundred years for medical science to describe its effects on the immune system.

Apparently that was the big breakthrough since by 1997 there were 66,000 literature citations on this master antioxidant, and just ten years later, there were 77,000.

So here we are, now entering the second decade of the 21st century and GSH is still not very well known among practicing physicians. Why is that?

It's the same old story over and over. The building blocks of glutathione can be taken as a supplement and that is the death knell in the medical community. If it's not an FDA approved drug that the doctor can prescribe, then forget it.

Also, doctors don't have time to read all the articles being published in medical journals and they don't teach natural health and supplementation in medical school. Again why is that? Just ask who largely funds medical schools today and the path leads directly to the pharmaceutical industry. They don't like supplements.

To begin, glutathione is a powerful antioxidant created in our cells that has been shown to fight cellular inflammation, detoxify cells, improve liver function and support the immune system.

Glutathione (GSH) is a tri-peptide and not an essential nutrient since it is synthesized from three amino acids:

• L-cysteine (CYS)
• L-glutamic acid (GLU)
• glycine (GLY)

In fact none of the three amino acids are essential nutrients either since all of them can be synthesized from various proteins that we consume.

L-cysteine is synthesized from the essential amino acid methionine.

L-glutamic acid is synthesized from glutamine (among others) and its salts (electrical neutral compounds) are called glutamates of which our old friend and headache maker, MSG (monosodium glutamate) is one.

Glycine is synthesized in the body from the amino acid serine.

GSH is synthesized in the cell by way of two adenosine triphosphate (ATP) dependent steps.

Recall that adenosine triphosphate (ATP) is created in the mitochondria of the cell and is used as a source of chemical energy. For this reason, mitochondria are often referred to as the cells power plant.

ATP is a cofactor; that is, a chemical compound that is required for the protein's biological activity. These proteins are commonly enzymes and cofactors (or coenzymes) and can be considered "helper molecules and/or ions" that assist in biochemical transformations.

Do the Two-Step

Having reviewed ATP, we can now describe steps one and two in the synthesis of glutathione.

In step one, two of the three amino acids, L-glutamate and L-cysteine, in conjunction with an enzyme, gamma-glutamylcysteine synthetase (glutamate cysteine ligase, GCL), form the protein gamma-glutamylcysteine.

This first step is rate limiting; in other words, it controls how fast glutathione can be synthesized.

In step two, the third amino acid, glycine, is added to gamma-glutamylcysteine (the product of step one), using another enzyme glutathione synthetase. The product of step two is glutathione.

As you might have gathered, any chemical substance that ends in "ase" is most likely an enzyme. Amylase and lipase are two enzymes in saliva that break down protein and fats respectively.

Size Matters

A logical question might be, "Why does glutathione have to be synthesized in the cell?" and the answer is that the GSH molecule is too big to be taken into the cell directly; thus the building blocks (the three amino acids) enter the cell where the ATP already resides and then the two-step construction process can proceed.

Attempts have been made to create GSH supplements but have not been very successful due to the small molecular size plus the fact that when the preformed GSH hits the digestive tract, the proteins get digested and it is destroyed.

So even if it were of a size suitable for absorption, the digestive environment would preclude it from ever having a chance to be absorbed.

Our choices then become one of ensuring that we get enough of the three glutathione building blocks in our food or supplement with the three components (or both).

There are also several other natural substances that enhance the conversion of proteins to GSH and are necessary for the recycling of glutathione, both of which will be discussed shortly.

Glutathione has multiple functions including:

It's most important role by far is that of antioxidant, in fact it is the master antioxidant. There are four antioxidants produced by the body as opposed to antioxidants we ingest such as vitamins C, E and D3 for example.

Those produced by the body are called endogenous antioxidants and consist of glutathione, superoxide dismutase, catalase and coenzyme Q 10 (CoQ10). From the names, it is obvious that the last three are enzymes (enzymes end in "ase") while GSH is the tri-peptide amino acid compound.

The Aging Problem

While glutathione is produced by the body, the bad news is that its production starts to decline steadily after age 20 or so. As GSH production declines, unresolved free radicals increase.

The result is more and more diseases of aging and general deterioration of the body. The consequences of decreased levels of GSH are numerous and include:

The whole list shown above can be boiled down into just a few statements.

Without GSH every cell in our bodies would die prematurely from its own waste products; the entire immune system would cease to function; the liver would cease to detoxify the body of all the toxins we ingest daily; and with a total absence of GSH, oxygen based life would be no more.

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Since GSH synthesis depends on the presence of certain amino acids, it figures that most foods rich in protein would be good sources of the basic building blocks, and they are.

L-cysteine is found in most high-protein foods, including pork, sausage meat, chicken, turkey, duck, luncheon meat, eggs, milk, whey protein, ricotta, cottage cheese and yogurt. Vegetable sources include red peppers, garlic, onions, broccoli, Brussels sprouts, oats, granola and wheat germ.

Whey protein contains 8 times more of the amino-acid cysteine than casein, a protein that accounts for about 80% of the protein in cow’s milk and cheese. However, it is important that if one is supplementing whey protein for GSH production, it must be bio-active, meaning not denatured and not pasteurized.

L-glutamic acid comes from all meats, poultry, fish, eggs and dairy products. An edible kelp known as kombu, or konbu, in Japan is extremely rich in glutamic acid. In addition, some protein-rich plant foods are also good sources, Ninety-five percent of the dietary glutamate is metabolized by intestinal cells.

Glycine also comes from high-protein foods, such as fish, meat, beans, milk, and cheese.

If the protein building blocks are so plentiful in such common foods, why should we ever have low GSH levels, especially as we age? The answer most likely is in the cooking and preparation.

These proteins are delicate and can be injured or destroyed by heat or by rapid agitation such as blending. So we think we are getting a lot of the three amino acids from eggs? Not if they are fried, poached, scrambled, hard boiled or whipped into a froth and baked into grandma’s pies and cakes.

For GSH purposes at least, raw is the way to go when it comes to eggs and other amino acid containing foods. So who eats raw eggs, raw meat or raw fish (besides the Japanese)? Not many people in North America.

Well, that leaves us with glutathione supporting supplements. Read on.

There are several products on the market that attempt to function as glutathione supplements but two stand out and are discussed below.

None of them involve the direct intake of glutathione for reasons previously given; namely that it doesn't work. Rather they take the more proven approach of providing nutrients that cells can absorb and use to produce GSH. Furthermore, both of them use the network marketing sales model and none of the products are sold in retail establishments.

Max International, LLC

Cellgevity^TM, from Max International in Salt Lake city, Utah, is a product uniquely designed and focused on supporting the cellular production of glutathione. It is arguably the best, most effective product of its type on the market today; in fact, due to the company’s tight patents, it may be the only product of its type on the market.

Cellgevity incorporates the GSH building blocks and supporting nutrients into its menu of ingredients.

Photo: Copyright Max International, LLC. All rights reverved.

Reading the label,we find that Cellgevity has 125mg of RiboCeine^R, also known as D-Ribose-L-Cysteine. According to company literature, "RiboCeince is a breakthrough nutrient compound of epic proportion that has been shown to effectively deliver the key precursor nutrient into the cell that enables it to produce optimal amounts of GSH."

The GSH recycling and absorption blend consisting of 580 mg of cordyceps, curcumin/black pepper, resveratrol, alpha lipoic acid, grape seed extract, quercetin, milk thistle extract, broccoli extract, acemannan Aloe Vera extract and BioPerine is a super supporting cast for the GSH toolkit.

MAX International is a young company, having been founded in February 2007 and if all goes as planned, should become a household name in the health and wellness industry. So far it is a privately held company.

As an independant associate of Max International, I invite you to Visit Max for more information about its products, to order or become a Preferred Customer or even an associate yourself to take advantage of this ground floor opportunity. You are also free to contact me for further information on Cellgevity or any other of fine Max International products and how to obtain them.

Immunotec, Inc.

The next product to be discussed is Immunocal from Immunotec, Inc. in Quebec, Canada. Immunocal is a public company, listed on the Toronto Stock Exchange under the symbol IMM.

They provide a glutathione support product based on the amino acid building blocks but take a different approach than does Max International. Immunocal gets its building blocks (the GSH precursors) from whey protein.

Their product is described as an "all-natural non-prescription health product available worldwide". It is also patented worldwide.

Immunocal is the result of years of research by Dr. Gustavo Bounous, MD who is a strong believer that "nature holds many secrets for optimal health. Secrets that are hidden and waiting to be discovered by anyone willing to put in the time and effort necessary to uncover them."

Sounds a bit like the quote from Paracelsus who said, "All that man needs for health and healing has been provided by God in nature, the challenge of science is to find it." Therefore the physician must start from nature and proceed with an open mind.

From company literature, it takes about 125 gallons of fresh raw milk to make a pound of Immunocal.

The end product is a derivative of whey protein isolate engineered to have the highest amounts of glutathione precursors possible.

Before talking about what GSH is, and what it does, let’s look at some of the benefits of taking Immunocal, besides its clinically-proven ability to raise glutathione levels.

Whey protein, especially whey protein isolates (over 90% protein); supply most of what we need for muscle mass generation.

It is sometimes referred to as the “perfect” protein, because it contains all the essential amino acids required for the body’s protein synthesis. With a biological value (BV) of over 110, it would be challenging to find a whey protein utilized more efficiently than Immunocal.

Immunocal's website is http://www.immunocal.com/ or if you want more in-depth reading on Immunocal or whey protein, a couple of recommended websites are:

"Glutathione: New Supplement on the Block" at MedicineNet.com is an article from WebMD that talks a bit about Dr. Bounous and Immunocal. Click on "Cure-all or Snake Oil" by Alison Palkhivala to read it.

For information on whey protein, click on A Former Fat Guy's website, which would be Will Brink, a fitness columnist and writer for various fitness, medical and body building publications who has written an article covering everything you want to know about whey protein and its processing.

As we alluded to earlier, supplementing GSH directly has been difficult. Research suggests that it is not well absorbed in the Gastrointestinal tract due to its molecular size and acidic environment of the digestive tract.

In a study of oral administration of a very large dose (3 grams) of GSH, it was found that it is not possible to increase circulating glutathione to a clinically beneficial extent by the oral administration of a single dose of 3 g of glutathione.

The following is a U-tube video by Dr. Mark Hyman, M.D. and co-author of the "UltraPrevention" books that have been highly recommended throughout this "Healthy by Nature" website.

It would be productive and highly informative to take time now to watch this nine minute video and then read on for additional discussion of Dr. Hyman's comments on GSH supplementation. To my knowledge, Dr. Hyman is not selling any products and his tutorial should be totally unbiased by commercial considerations.

As Dr. Hyman alluded to in the video, there is a genetic connection to low GSH levels. A gene designated GSTM1 (glutathione S-transferase Mu 1) is a human glutathione S-transferase (GST) enzyme thought to play a role in the biotransformation of pollutants, drugs, toxins, all generally known as xenobiotics.

GSTM1 is one of the family of glutathione S-transferases, which allow GSH to interact with harmful organic hydroperoxides to neutralize and excrete them from the body.

There is strong evidence linking chronic fatigue syndrome and GSTM1 dysfunction. It is possible that the effectiveness of GSH supplementation in those with chronic fatigue syndrome may be in part dependent upon their genetic status with reference to the GSTM1 gene. It is also possible to possess a mutant genetic makeup (GSTM1-0/0) that does not allow for the production of GSH.

It has been estimated that 40-60% of the population may have two copies (one from each parent) of the same mutant form of the GSTM1 gene, lacking that gene's normal function. The health outlook for chronic fatigue patients with GSTM1-0/0 is worse than for those who do not possess that genetic make-up.

If someone is in that population without an active GSTM1 gene, they may need to compensate by eating more broccoli or by eating “super broccoli” that has higher levels of the active plant chemical sulforaphane. Consuming larger portions of broccoli or super broccoli makes it possible to retain greater amounts of sulforaphane not to mention other vitamins and minerals.

Considering that most of us have no idea what type of GSTM1 gene we carry nor do we know how much broccoli is enough, eating broccoli and other cruciferous vegetables as part of a healthy lifestyle is highly recommended.

If someone can't handle all that broccoli, then consider broccoli sprouts in salads or on sandwiches. They are higher in sufloraphane anyway.

Genetics aside, as Dr. Hyman stated, as we age our levels of glutathione steadily decline.

This correlates with his observations that the lowest GSH levels are seen in the oldest, sickest, hospitalized patients and the highest levels in the younger, healthier individuals. The charts shown above and to the right illustrate this quite well.

The good news is that with supplementation with GSH accelerator products such as Max International's Cellgevity, MaxGXL or MaxOne, glutathione levels are restored across all groups, both the healthy and catastrophically ill.

The chart above illustrates the remarkable increase in GSH after even short periods of supplementation.

The Methylation Cycle

Methylation refers to the attachment or substitution of a methyl hydrocarbon group on various molecules through the interaction of appropriate enzymes.

It's called methylation because the hydrocarbon in question is methane and in human biochemistry, a hydrogen atom gets replaced with the methyl group.

Dr. Van Konynenburg, PhD., an independent researcher in glutathione and the methylation cycle for many years, believes that the fundamental biochemical issue in a large subset of chronic fatigue syndrome (CFS) patients is that the methylation cycle is blocked. The main goal of this treatment approach is to remove this block and restore the methylation cycle.

He also believes that glutathione depletion is directly responsible for many of the features of CFS, but that it is usually not possible to normalize the GSH levels on a permanent basis by direct supplementation of glutathione building blocks.

Rather, the methylation cycle block must be corrected first to break the cycle that is holding down the glutathione levels. In addition to this, about one-third of CFS patients, because of particular genetic mutations described in the previous paragraph, cannot tolerate supplementation with GSH or other substances intended to help them directly build glutathione.

In biological systems, methylation is enabled by enzymes and is extremely important in several areas. Methylation can be involved in modification of heavy metals, regulation of gene expression, regulation of protein function, and RNA metabolism. Methylation of heavy metals can also occur outside of biological systems.

Thus, if the process is blocked and unable to occur, we will have problems in a lot more areas than chronic fatigue.

For a very comprehensive article on the methylation cycle including a list of supplements to take to get the cycle kick-started once it has stalled, go to Dr. Myhill's site, "CFS-The Methylation Cycle-Updated May 2009".

Clinical Trials

The 70,000 to 80,000 papers submitted on glutathione are backed up by numerous clinical studies. There is no doubt about the importance and function of GSH on one’s health. So we can safely talk about the benefits of glutathione all day without worry.

What we cannot do, is promote a specific GSH support product with cure or healing claims unless it has been through the FDA's New Drug Application process and been approved for use with a specific health condition.

Suffice it to say that there are literally hundreds of trials that have been conducted or are being conducted now. The link to "Psych Drug Truth" shows a page from an intensely interesting and informative website dealing with psychotropic drugs and how to safely get off them.

This linked page deals with GSH and, what is interesting about it, is that it contains probably 200 or so links to Glutathione related PubMed articles detailing many of the aforementioned clinical trials.

Besides the actual amino acid building blocks of GSH, there are a number of nutrients that must be present for optimal absorption of the building blocks by the cell.

Mandatory supplements for general health are a high quality omega-3 fish oil to help control the production inflammation agents such as leukotrienes and prostaglandins. A high quality, natural multi-vitamin, mineral and phytochemical formulation is also mandatory.

Then we come to the GSH absorption enhancers.

Alpha Lipoic Acid (ALA) is mentioned first because cellular energy in the form of Adenosine Triphosphate is needed to drive the process that builds glutathione in the cell.

ALA is a fatty acid found naturally in every cell and it converts glucose into energy. It is also a strong antioxidant in its own right but also works to recycle other antioxidants such as vitamin C and depleted glutathione (GSSH) back to a useable form. Stated plainly, Alpha Lipoic Acid increases the formation of glutathione.

The "Bee's"

Next we have to mention the B vitamins; B₆, B₁₂ and folate.

B₆ (pyridoxine) is required in the functioning of about 100 enzymes that catalyze or speed up chemical reactions in the body. A form of B₆ is needed to create glucose from amino acids and we already saw that ALA works on glucose to create energy.

B₁₂ (cobalamin) is required for the activity of only two enzymes in the human body, methionine synthase and L-methylmalonyl-CoA mutase. Remember the prior discussion of the methylation cycle?

Methionine synthase is required for the synthesis of the amino acid, methionine, from homocysteine. Methionine in turn is required for the synthesis of S-adenosylmethionine, a methyl group donor used in many biological methylation reactions, including the methylation of a number of sites within DNA and RNA.

So it appears that B12 is critical to the proper functioning of the methylation cycle.

Folate or folic acid is vitamin B₉. It helps produce and maintain new cells and is needed to make DNA and RNA, the building blocks of cells. It has a vital protective nature in helping prevent changes to DNA that may lead to cancer.

Folate is also essential for the metabolism of homocysteine, and helps maintain normal levels of this amino acid. From prior discussions, we know that high levels of homocysteine is a strong marker for heart disease.

Selenium

Selenium is an essential mineral and micronutrient which is required for biologic activity in proteins to occur; in other words, it is a cofactor.

It is needed for the reduction of the oxidation number of an atom in antioxidant enzymes such as glutathione peroxidases. Glutathion peroxidases are a family of enzymes that work mainly to protect an organism from oxidative damage.

So the bottom line is that the incorporation of selenium into proteins acts to prevent cellular damage from free radicals and thus it is usually found in glutathione support supplements.

Milk Thistle

If the word silybum or silymarin appears on a supplement label, you can be sure it is the Milk Thistle herb. For some 2000 years herbalists have been using the seeds to treat chronic liver disease and protect the liver from toxins.

Extracts of milk thistle are now used to treat cirrhosis of the liver, chronic hepatitis and toxin induced liver damage. The latter includes acetominophen damage which has been getting a lot of press recently

Silymarin, or milk thistle, has antioxidant and anti-inflammatory properties, and it may help the liver repair itself by growing new cells. Thus it is no wonder that such an herb would be included in the formulation of a glutathion support supplement.

Quercetin

Quercetin is one of the phytochemical flavonoids and if you see a red skin on apples or onions, you will know that quercetin is present. It is a powerful antioxidant and has been shown to have anti-histamine and anti-inflammatory benefits.

The American Cancer Society says that while quercetin "has been promoted as being effective against a wide variety of diseases, including cancer," and "some early lab results appear promising, as of yet there is no reliable clinical evidence that quercetin can prevent or treat cancer in humans."

That statement doesn't mean that quercetin can't or won't help fight cancer cells, it just means that reliable testing acceptable to the FDA hasn't been conducted.

Cordyceps

Cordyceps is a fungus long used in Chinese medicine where it was valued in restoring energy and promoting longevity. It affects numerous human body systems including the circulatory, respiratory, and immune systems, as well as the liver and kidneys.

According to Sloan-Kettering, "Cordyceps stimulates the number of T helper cells, prolongs the survival of lymphocytes, enhances TNF-alpha and interleukin 1 production, and increases the activity of natural killer cells in cultured rat Kupffer cells".

"Another study shows that cordyceps may be effective against tumor celIs by down-regulating MHC class II antigen expression. In addition, anecdotal data suggest reduction of cyclosporin and aminoglycoside-induced renal toxicity, although the mechanism of action is not known". Their references can be seen at Cordyceps.

While Cordyceps is good for us humans, it's a true horror movie for the insect world. The short video below is embedded here just for the fun of it. Be glad you're not an ant in the jungle.

Throughout this article, one might wonder how GSH levels are measured in the body and why it isn't done as a routine thing whenever we visit a doctor's office. Is it complicated, expensive, time consuming and reliable? Yes, to all of those items.

Why isn't a simple test kit available that can be used to get a quick reading on our GSH levels? There is; in fact several of them, but they are also expensive and unless one really knows what they are doing, it is best that a trained medical practitioner in this area conduct and interpret the test.

Quite a few patents have been issued for glutathione testing methods.

A Culture Testing Approach

A more recent one is U.S. Patent #7279301, issued October 9, 2007 to J. Fred Crawford, titled "Methods of determining Deficiencies in Intracellular Levels of Cysteine and Glutathione". It uses cultures of various mediums to assess the growth of lymphocytes in response to the addition of or withholding of specific nutrients.

From "Patent Storm", we read the description as, "The present invention relates to the measurement of levels of intracellular function of cysteine and GSH so as to provide one measurement of an individual's capability of preventing degenerative disease and dealing with oxidative stress. If anyone is interested, the URL is:

"http://www.patentstorm.us/patents/7279301/description.html".

An Optical Density Approach

Way back in 1975, US patent No. 3864085 was assigned to Princeton Biomedix in Princeton, NJ. for "A method for the Quantitative Colorimetric Determination of Reduced Glutathione in Blood".

The method involves mixing a sample of blood with a reagent containing stabilized tungstic acid, ethanol, and 5,5'-dithiobis (2-nitrobenzoic acid). The mixture is centrifuged and the optical density of the supernatant is measured.

The supernatant is mixed with a buffer to get a final pH of from about 7 to about 10, and the optical density is again measured. The glutathione concentration is determined from the optical density measurements. For interested parties, the URL for this patent is:

"http://www.freepatentsonline.com/3864085.html".

A Flow Cytometry and Fluorescing Laser Approach

A small randomized controlled trial of oral N-acetylcysteine(NAC), organized primarily by Drs. Leonard and Leonore Herzenberg, both PhD’s, at Stanford University, and designed by them and Greg Dubs, Ph.D., who conducted the trial -- was run in San Francisco in 1993 and 1994.

They examined the survival rates of HIV patients against their levels of glutathione.

GSH levels were measured within individual cells, using flow cytometry, the same technology used to measure CD4 and CD8 cell counts.

The "CD" stands for "cluster of differentiation or cell differentiation glycoproteins" CD4 is a name given to T-helper cells, white blood cells that fight infection, and CD8 refers to suppressor T-cells.

Blood cells from the patient were treated so that the glutathione within the cells was changed chemically, to a florescent substance which glowed when hit by certain laser light. The strength of the glow, indicating the concentration of glutathione in that cell, was measured as the cells were passed single file through a small tube, and the result for each cell was separately recorded by a computer.

To help check that the technology was working correctly, the glutathione level in CD4 cells was correlated with that in the blood (measured by more standard chemical tests), and with that in CD8 cells, monocytes, natural killer cells, and B-cells.

The glutathione levels turned out to be comparable no matter where they were measured. The Herzenberg’s developed the use of flow cytometry for medical purposes and their laboratory is among the best in the world in using this technology. The URL to read more about this method "http://www.aids.org/atn/a-266-01.html".

Test Kits

A quick search of the internet found several companies offering glutathione test kits. The two mentioned below were selected just for the purpose of showing that they are available and to give an idea of their cost.

1. A total Glutathione Detection Kit is offered by Assay Designs for $330.00. It is labeled as a "Creatinine Colorimetric Detection Kit" and uses a urine sample to normalize it with creatinine. The URL is:

"http://www.assaydesigns.com/commerce/ccpa1014-6413-6413-glutathione-28total29-detection-kit.htm".

2. A test kit from BioAssay Systems in Hayward, CA. called the "QuantiChrom Glutathione Assay Kit" is based on a quantitative colorimetric assay of reduced glutathione. It takes 30 minutes and costs $279 for the kit. The URL to see this kit is:

"http://www.bioassaysys.com/Search.asp?Key=DIGT".

How about a cosmetic application for the Mother of all Antioxidants.

Who would ever believe an antioxidant could be used to lighten dark skin? Nevertheless, GSH has recently been used by the cosmetics industry to inhibit melanin. Melanin is the substance that gives skin its color and is formed as part of the process of metabolizing the amino acid tyrosine.

It's not so hard to believe knowing that GSH is the product of enzyme reactions on several amino acids driven by cellular adenosine triphosphate. Melanin production is dependent on reactions involving the amino acid enzyme tyrosinase and the dopamine precursor L-Dopa.

GSH has been shown in studies to inhibit melanin synthesis in the reaction of tyrosinase and L-DOPA.

When melanin synthesis was inhibited, it was restored by increasing the concentration of L-DOPA, but not by increasing tyrosinase indicating that GSH inhibited the binding between tyrosinase and L-DOPA. Although the synthesized melanin was concentrated within an hour, the aggregation or concentration was inhibited by the addition of glutathione.

These results indicate that glutathione inhibits the creation and joining of melanin molecules by interrupting the function of L-DOPA. The end result of the inhibition is a reduction of melanin in the skin and thus a lighter skin color.

So because of the relationship between GSH, L-dopa and tyrosinease, we have a whole host of cosmetic products designed to make dark skin lighter. In several countries, glutathione products (or counterfeit GSH) are sold as whitening soaps, creams or lotions.

GSH and Acetaminophen

Acetaminophen, the active ingredient in Tylenol, has been in the news lately for its implication in liver failure.

The FDA will likely put new restrictions on acetaminophen per an advisory committee recommendation, saying "the move would protect people from the potential toxicity that can cause liver failure and even death".

The implications for glutathione and treatment of acetaminophen toxicity are impressive.

Baby mice have a story to tell. While every cell in the human body is capable of synthesizing GSH, liver synthesis of glutathione has been shown to be essential.

If fetal mice are genetically modified to block the synthesis of GSH only in their liver, they will die within 1 month of birth. So the ability of the liver to correctly construct glutathione would seem to be a life or death proposition.

Thus it follows that if acetaminophen toxifies a liver to the point of failure and knowing that GSH is the best antioxidant and detoxifying agent known and if GSH levels in the body and liver in particular are low, the patient’s fate is sealed.

The very scientific description of the acetaminophen and glutathione reactions as given in Wikipedia is,

"GSH is known as a substrate in both conjugation reactions and reduction reactions, catalyzed by glutathione S-transferase enzymes in cytosol, microsomes, and mitochondria.

However, it is also capable of participating in non-enzymatic conjugation with some chemicals, as in the case of N-acetyl-p-benzoquinone imine (NAPQI), the reactive cytochrome P450-reactive metabolite formed by acetaminophen that becomes toxic when GSH is depleted by an overdose of acetaminophen".

and furthermore...

"Glutathione conjugates to NAPQI and helps to detoxify it, in this capacity protects cellular protein thiol groups, which would otherwise become covalently modified; when all GSH has been spent, NAPQI begins to react with the cellular proteins, killing the cells in the process.

The preferred treatment for an overdose of this painkiller is the administration of N-acetyl-L-cysteine, which is processed by cells to L-cysteine and used in the de novo synthesis of GSH."

What all this means in plain English is that if we take large doses of Tylenol (or any acetaminophen compound) we should keep our GSH levels as high as possible because it protects and detoxifies the liver. Now wasn't that easy?

Closing the Page on Glutathione

In leaving "Glutathione", the message should be clear that everyone needs to maintain their intracellular levels of GSH as high as possible and the only way to do that these days is through supplementation.

Contact Me for more information on products containing the glutathione building blocks, whey protein and GSH support nutrients. It is never too late to start; well it might be too late when they start to shovel the dirt onto our casket.

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