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The first brain nuclei involved in the addiction process is the ventral tegmental area (VTA), a very small area in the midbrain just below and forward of hippocampus and behind the amygdala. It connects to the other nuclei of the endogenous reward system; the nucleus accumbens septi (NAS), the orbitofrontal cortex (OFC) and the prefrontal cortex (PFC). Dopamine is the neurotransmitter used by the ventral tegmental area and in every case of addiction, the nucleus accumbens septi are involved. All of this projects to the brain's left hemisphere where it stimulates the left prefrontal area of the pleasure system. Biochemical Mechanism of Substance AbuseDopamine provides feelings of enjoyment and through the reinforcement mechanism, motivates a person to seek out opportunities to engage in pleasurable activities. It is released in the nucleus accumbens septi and prefrontal cortex by naturally rewarding experiences such as food, sex, drugs, and neutral stimuli that become associated with them. This theory is widely discussed in terms of substance abuse of cocaine, nicotine, and amphetamines. These substances seem to lead to an increase of dopamine in these areas and it is believed that these dopamine pathways are pathologically altered in addicted persons. In addition to pleasurable activities, recent studies indicate that aggression may also stimulate the release of dopamine thus leading to an increase in aggressive behavior. There is an ample amount of clinical evidence based on animal research that supports the addictive side of dopamine. Researchers put electrodes in the pleasure centers of the animal's brain and train them to press a bar to get an electrical stimulation. Observations were that they will keep pressing the bar to receive the pleasurable stimulus to the point of exhaustion and even starving to death for the pleasure response. Who would imagine that death by substance abuse would feel so good? These are the same areas that are stimulated under natural or normal conditions by eating, drinking or sex. But as shown in the clinical research, drugs such as cocaine can stimulate these pathways and the test animal will hit the bar for a bit of cocaine and refuse sex, food and anything else to get that hit of coke. It was not unusual for the addiction to manifest from very first hit. Individuals who are cocaine addicts talk about whole body euphoria and elation that a non-user can't imagine. On MRI, pleasure areas of brains light up, and in imaging studies of human brains, even the anticipation of pleasure stimulates these areas. In humans, the greatest activation of brain response occurs when anticipation is paired with some degree of uncertainty. This may explain why gambling as an addiction may be as hard to overcome as substance abuse. Substance abuse can damage the endogenous reward system or alter it to the extent that it can destroy an individual's ability to enjoy life.
A logical question would be why don't we just administer drugs to increase dopamine levels to help people beat depression since it seems to trigger such feelings of pleasure or euphoria? Photo above: Brain activity of non-user versus user Actually it's been tried and found that increasing the levels of dopamine produces mania; just the opposite of manic depressives. Patients are hard to manage in that they are very non-compliant with their meds. They don't want to be leveled out, they want to stay high and experience the euphoria. Falling in love is an example of the intense high; some people have these areas stimulated by learning or taking courses or reading good books or the joy of experiencing nature. We should not minimize the experience just because it is a chemical reaction. Understanding how the brain works doesn't make the normal, pleasurable experience any less important. Drugs Effect on The Endogenous Reward SystemSubstance abuse of drugs work at the cellular and molecular levels to highjack the endogenous reward system. All psycho active drugs operate on the limbic system and can be physiologically and psychologically addicting, driving the person to seek out the drug. There may be genetic factors at work as well. Cocaine is highly addicting to most people but not so much to others. Some can become dependent on drug but not physically addicted. Females are more prone than males. Clearly, there is a lot more research to be done in this whole area of substance abuse and why it hits some people harder than others. Coke is a highly addictive psychostimulant that blocks the reuptake of serotonin and dopamine. Its major targets are the projections to the frontal cortex area where it hits dopaminergic sites in the Nucleus accumbens septi and prefrontal cortex. Photo: Coca plant (Erythroxylon Coca)
All addictive drugs involve the nucleus accumbens septi. Furthermore, the projection from ventral tegmental area to the NAS is believed to play a role in the behavior of addicts when seeking out a drug. Coke blocks the reuptake of dopamine from cleft of synaptic terminals and without the reuptake; a lot of neurotransmitter is left in the cleft to keep stimulating. It throws off the workings of the synapse. There is an initial intense stimulation providing elation, or the "high" as some call it. The brain doesn't like it when the stimulation goes to the nucleus accumbens and prefrontal cortex so it compensates. The compensation takes the form of an intense "crash" characterized by depression, irritability, anxiety and lethargy. The crash then promotes more craving and a need for higher doses of the drug to get the same effect since the synaptic receptors have also had their sensitivity downgraded. So what we end up with is a rapidly accelerating pattern of drug use and crack cocaine use shown in the photo below is one of the hardest of all to overcome.
Long term use of coke may produce permanent changes in responsiveness of neurons in the reward system including a decreased responsiveness to dopamine and down regulation in the synthesis of opioids. Over time we see an emotional blunting in the individual that contributes to recidivism since normal things in life that make us feel joy are gone. Giving up a drug can even trigger a grief response and cause a loss of appreciation for things that the person used to love. Love of music or the arts or reading may no longer appeal to a recovered addict. Orbitofrontal area (OFA) of the brain is involved in impulse control, moral mores, and awareness of the consequences of one’s actions. Thus, if the OFA is highjacked, we will see bizarre behaviors void of moral guidance. A common example cited is a woman giving her 12 year old daughter to a drug dealer for one hit of coke. Cocaine is one thing... |
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After wading through all that deep science and mind-numbing physiology, the only question now is..."If I, or someone I know, is hooked, how do we get off it?
I accept that the drugs and alcohol have rewired my brain and the craving is intense but is there any hope? With regard to restoring the brains neurological connections to the way they were before the addiction took hold, we have a good news, bad news situation.
The good news is that a research team at the University of California studying the reversal of substance abuse has shown how blocking the flow of a specific chemical in the brain blocks the sensitization to a drug in lab rats.
Sensitization is what the researchers called the increasing levels of dependency and craving leading to addiction. The problem here is that the chemical has to be blocked before a person starts on the drug; once addicted, it won't help or reverse the condition.
Another group of researchers at the University of British Columbia in Vancouver has been working on ways to restore the brain connections that existed before the use of the addictive substance. It seems to have worked in experiments with amphetamine addicted mice in which their addiction memory circuits apparently were rewired to erase the memory, and thus the craving, of the amphetamine.
Now the bad news is that victims of substance abuse probably won't benefit from this research for at least 15 to 20 years.
Yet millions of addicts have put all kinds of substance abuse behind them, but don't think it's easy or painless.
First of all there is likely to be an emotional adjustment; a period of deep depression brought on by a sense of loss. An alcoholic or drug addict, having given up the substance of choice will often go through a very real grief response; much like losing a spouse or a long-time lover.
Then there are the biological impacts of substance abuse to deal with and for these we will confine the discussion to alcohol.
Alcohol bypasses the normal digestive process and goes directly to the blood stream through the stomach wall and small intestine. The alcohol hits every organ and tissue in the body within minutes after entering the blood stream. The Blood-alcohol level is a measure of the amount of alcohol in the blood stream.
If someone has a blood-alcohol level of .03, it means that they have 3 parts alcohol per 10,000 parts blood.
Thirty parts alcohol per 10,000 parts blood is the minimum level that can cause death; Forty parts can cause coma; fifty parts and the respiratory and heart slows drastically and at 60 parts most people are dead; not dead drunk, just dead.
A long term alcoholic who wants to get sober for good will have a lot of systemic damage to deal with and will be faced with some serious rehab time to repair that damage.
Starting with the liver, the body's greatest filter, a large amount of fat will have built up which may have brought on hepatitis (inflammation) or worse, cirrhosis of the liver. All of this substance abuse will lead to a buildup of fats in the blood stream leading to cardiovascular problems.
The brain suffers most with long term alcoholics. The changes that substance abuse causes in the brain discussed above result in a tolerance for alcohol and a dependency on it.
Other noticeable signs of damage are loss of memory, confusion and extreme, rapid mood swings. At least these can be controlled and even reversed by stopping the drinking.
Tens of thousands of neurons will die with every episode of intoxication due to lack of oxygen usually accompanied by blackouts.
Even blood is affected by chronic alcohol abuse. Red blood cells tend to clump together causing small vessels to plug up, thus starving the tissues of oxygen resulting in cell death. Obviously, this is most serious in the brain as mentioned above.
The increased pressure of plugged capillaries causes them to break resulting in the characteristic morning red eyes, blotchy skin on the alcoholics face and hemorrhaging in the stomach and esophagus. Serious? Yes, deadly serious.
The pancreas is often damaged from substance abuse to the point of shutting down and ceasing to produce insulin. This condition is purely from overwork where the pancreas is forced to produce an unnatural amount of insulin to deal with the high level of blood sugar that alcohol produces. Diabetes is very common in alcoholics.
Alcoholic’s muscles are typically weak and deteriorated due to reduced blood flow. Since the heart is a muscle, a sluggish heart with irregular beats is common.
Finally, in men we see some strange changes in sexual function from prolonged substance abuse, particularly with alcohol. Alcohol sedates all the endocrine glands resulting in an under production of hormones which causes shrinkage of the testes and an increase in the female hormone estrogen.
If a guy wants enlarged breasts and loss of body hair, keep on chugging. Sexual performance...forget it! Where alcohol is concerned, substance abuse can decrease the frequency and quality of erections and that once powerful tool will become a "teeny-weeny".
Is that enough reasons not to become addicted to alcohol?
When we think of withdrawal, we usually think of hard drugs but going cold-turkey with alcohol has very definite and very unpleasant withdrawal stages.
Withdrawal from those occasional periods of serious drinking or in people with only a mild dependency will include the familiar hangovers, sleep disturbances, possibly irritability and morning shakes.
More deeply dependent alcoholics will experience "second stage" withdrawal symptoms that may involve convulsions or seizures usually occurring from 12 to 48 hours from the last drink. If the severity is extreme, loss of consciousness and body control may occur.
What I call the down-in-the-gutter alcoholics will go through "third stage" withdrawal symptoms which are marked by hallucinations and delirium tremens or the DTs.
During de-tox, these can last three or four days, in which the person is in a severe state of agitation, sometimes violent, totally disoriented and can't sleep. It is a terrifying experience and between 10% and 20% may not survive without close medical supervision.
Many drift in and out of rehab, in and out of recovery, getting a little taste of how good life can be, and then slipping back into addiction. Why?
Let’s look at the nutritional considerations of substance abuse first then move to the more subjective areas of desire, emotional state, willpower and support groups.
Heavy chronic drinkers will be severely depleted of micro nutrients so diet and supplementation become critical.
Start with an increase in protein intake. Adjusting the diet to include high amounts of protein will replace many missing nutrients and, more importantly, keep the blood sugar from changing too rapidly.
The caution here is to get those proteins from eggs, milk, vegetables and soy products instead of meat and cheese. The alcoholic liver will be full of fatty deposits and will not be able to process the extra fat from meat or cheese. When eating meat, fruit should be eaten with it to help break down those additional fats.
Vitamin and protein supplementation are important, especially vitamins A, B, C and E. The protein supplementation will help reduce the alcohol craving and aid in maintaining emotional balance.
The inclusion of complex carbohydrates can stabilize the blood sugar and alleviate the hypoglycemic (low blood sugar) state of the alcoholic and also help reduce the craving.
Now for the intangibles.
All we can do is examine the common characteristics of those addicts that have achieved long term sobriety and see how they did it.
We've heard that someone has to "hit bottom" before they can really come to terms with their substance abuse. It's not the hitting bottom that is significant, it's being able to admit complete defeat against drugs or alcohol and accepting the need for a change.
No one in the state of denial ever made a long term recovery. This can be summed up as a state of complete surrender.
Those alcoholics who have achieved long term sobriety in Alcoholics Anonymous usually tell how deeply involved they were in the recovery program. It's hard to achieve any level of success by dabbling in a recovery program.
Dabbling is not evidence of commitment and total commitment is what is required; it's an outward show what is driving a person towards a lifestyle of sobriety.
A driving level of desperation is needed to get someone struggling with substance abuse to follow directions given that any recovery program is mainly a set of directions leading to a drug free or alcohol free life.
Successful AA followers often share in meetings how they were willing to do whatever was asked of them in order to stay sober.
There are a number of mind adjustments that can help stay the course for the long haul. Great journeys are made one step at a time so instead of steps, focus on one day at a time. Don't look at the coming year or coming month or even a week; just get through today. Get through today and tomorrow will be a new fresh start.
Short term treatments are not likely to do a hard-core substance abusers much good no matter what the level of commitment. There are just too many habits that need to be changed and new lifestyle attitudes to develop.
Anyone with a chronic alcohol addiction should seek out a long term treatment center, facility or home. It will take a year or more to build a foundation for recovery and long term is the only approach.
The real key for a totally addicted alcoholic to find and live a life of sobriety is to find one's spirit. Having a spiritual awakening is not the same as a religious conversion.
For the substance abuser it means overcoming "self", putting self-centeredness behind and going through a change in psyche. Training in behavioral approaches and cognitive therapies are good but only go so far. Real success lies in that psychic change in personality and constantly reinforcing it by helping others in recovery.
Learning to keep balance in one’s life is another vital factor in the long road to sobriety. Too many recovering addicts trade one addiction for another such as swapping alcoholism for workaholism.
Willingness to change is present in the early stages of recovery but it must be maintained. It is usually done by trying new ideas, being open to criticism and overcoming fears.
Avoid standing still. The recovering alcoholic is either growing or regressing. There is no standing still.
Those who achieve long term sobriety are constantly finding ways to grow spiritually, pushing themselves to grow spiritually.
And finally, don't go it alone. Remember "No Man Is An Island"? Everyone struggling with substance abuse needs the help of others or a support group to succeed long term whether it's 12-step meetings, therapy, counseling or anything else that brings one into contact with a network.
Over the years thousands of books have been written on how to live with, deal with and recover from alcoholism and other types of substance abuse. According the the New York Times, the following are the top ten. You can click on the links shown beside each book to check prices and place an order from Amazon.
The first is a real classic from 1938 titled "Alcoholics Anonymous" which delves into the 12-step recovery program. Alcoholics Anonymous: The Story of How Many Thousands of Men and Women Have Recovered from Alcoholism/Third Edition
Second on the list is "Adult Children of Alcoholics" by Janet Woititz. It deals with problems experienced by people who grew up in an alcoholic home environment. Adult Children of Alcoholics
Third is the landmark book, "Codependent No More and Beyond Codependency" by Melody Beattie. They started out as two volumes and have now been combined into one book. Codependent No More: Beyond Codependency
Fourth is "Love is a Choice" by Minirth, Meier Hemfelt. It covers the causes of codependency and shows how God's love is an essential part of the healing process.Love Is A Choice - Recovery for Codependent Relationships
Fifth is "one Day at a Time in Al-Anon", a daily reader full of inspirational messages on Al-Anon's philosophy for everyday situations.One Day at a Time in Al-Anon
Sixth is "Serenity" by Robert Hemfelt. It is a companion to the 12-step process and includes the New Testament, Psalms and Proverbs. Serenity: A Companion for Twelve Step Recovery
Seventh is "The Dilema of the Alcoholic Marriage" from the Al-Anon Family Group.The Dilemma of the Alcoholic Marriage
Eighth is M. Scott Peck's 25-year best seller, "The Road Less Traveled"; A classic on traditional values and spiritual growth.The Road Less Traveled, 25th Anniversary Edition : A New Psychology of Love, Traditional Values and Spiritual Growth
Ninth is "A Spiritual Kindergarten: Christian Perspectives on the Twelve Steps" by Dale Ryan. It looks at why the 12-steps are just a starting point. A Spiritual Kindergarten: Christian Perspectives on the Twelve Steps
Last but not least is "Under the Influence" by Dr. James Milam and Katherine Ketcham. It is a guide to the myths and realities of alcoholism. Under the Influence: A Guide to the Myths and Realities of Alcoholism
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